While not as remote as the upper Amazon and Rio Negro regions above Manaus, the lower Amazon River is a treasure-trove of experiences both natural and cultural. Because this stretch of river has, relatively speaking, larger population centres, it also is home to bigger and more significant museums and research centres, and provides visitors with an excellent understanding of the progression of western culture into the Amazon Basin.
The Upper Amazon is truly one of the most fascinating wildlife destinations in the world.
The region includes the Jau National Park, a World Heritage Site, and numerous indigenous communities, including 'Caboclos' living in stilt houses along the river.
Besides the pristine natural and human environments, this part of the Amazon Basin is renowned as a mosquito-free region thanks to 'cauxi', a natural insecticide found in these waters.